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Table 6 Statistically overrepresented GO terms

From: Capsule-dependent impact of MAPK signalling on host cell invasion and immune response during infection of the choroid plexus epithelium by Neisseria meningitidis

GO Term

Con vs MC58

Con vs MC58siaD

Con + U0126 vs MC58 + U0126

Con + U 0126 vs MC58siaD + U0126

p-value

Number annotated

p-value

Number Aannotated

p-value

Number annotated

p-value

Number annotated

Cellular response to lipopolysaccharide

1.64 × 10–20

16

3.03 × 10–20

17

1.49 × 10–15

13

1.35 × 10–19

18

Cellular response to molecule of bacterial origin

3.39 × 10–20

16

6.55 × 10–20

17

2.68 × 10–15

13

3.06 × 10–19

18

Cytokine-mediated signalling pathway

4.08 × 10–20

22

2.22 × 10–21

25

5.17 × 10–12

16

6.30 × 10–19

26

Cellular response to interleukin-1

1.97 × 10–08

9

6.48 × 10–09

10

1.08 × 10–05

7

1.16 × 10–07

10

Regulation of NIK/NF-kappaB signalling

4.63 × 10–05

6

2.26 × 10–04

6

  

1.21 × 10–03

6

NIK/NF-kappaB signalling

5.84 × 10–04

6

2.78 × 10–03

6

    

Interleukin-6 production

1.93 × 10–04

6

3.37 × 10–05

7

  

1.00 × 10–05

8

Negative regulation of interleukin-6 production

9.11 × 10–04

4

2.68 × 10–03

4

4.99 × 10–04

4

8.35 × 10–03

4

Cell surface receptor signalling pathway

1.82 × 10–10

25

7.24 × 10–12

30

1.73 × 10–06

20

3.69 × 10–09

32

Signal transduction by protein phosphorylation

3.11 × 10–03

10

4.96 × 10–03

11

    

MAPK cascade

2.85 × 10–03

10

4.51 × 10–03

11

    

Positive regulation of MAPK cascade

3.93 × 10–03

8

2.99 × 10–03

9

    

Regulation of ERK1 and ERK2 cascade

7.13 × 10–04

7

4.27 × 10–03

7

    

JAK-STAT cascade

8.91 × 10–03

5

1.56 × 10–03

6

    

Negative regulation of cell death

2.99 × 10–08

15

6.62 × 10–11

19

1.79 × 10–04

11

1.76 × 10–06

17

Response to tumour necrosis factor

9.23 × 10–11

12

9.21 × 10–11

13

8.05 × 10–07

9

4.24 × 10–09

13

Regulation of tumour necrosis factor production

3.14 × 10–04

6

5.93 × 10–05

7

  

7.86 × 10–03

6

Regulation of tumour necrosis factor superfamily cytokine production

3.52 × 10–04

6

6.78 × 10–05

7

  

8.79 × 10–03

6

  1. The GO terms were determined on the basis of the different lists of DEG. The analysis was carried out with the LAGO software and an upper limit of 0.01 was applied as p-value with a Bonferroni correction. The GO terms, the corrected p-value and the number of analysed genes in the respective GO terms (number of genes) are shown