Fig. 1
From: Lithium administered to pregnant, lactating and neonatal rats: entry into developing brain
Determination of Injection Protocol. A Concentration of lithium in plasma of a litter of P4 rats administered lithium at concentrations of 3.2, 6.4 or 16 mg/kg body weight via i.p. injection, samples were collected 90 min after injection. Each dot represents an individual animal. Means ± standard deviation (SD). B–D Lithium 3.2 mg/kg body weight was injected i.p. into postnatal animals at the ages indicated; plasma and CSF were collected from pups at the post-injection times indicated. Each dot in B–D represents samples from individual animals; paired plasma and CSF for each pup are aligned vertically on graphs. Concentrations of lithium in un-injected control rats (P4) were below the limit of quantitation (LoQ).