Fig. 5

Ventricular volumes of intact (n = 4), sham-injected (n = 6), and kaolin-injected (n = 17) pigs. A–E Dot plots illustrating volumes for individual and combined ventricles. Note that the mean ventricular volume increased significantly in all ventricles in kaolin-injected animals compared to both intact and sham controls. No significant differences between sham and intact controls were found. The dashed lines in all ventricular volume graphs indicate 2.0 standard deviations from the sham control mean. This threshold was used to define the existence of hydrocephalus, such that all cases were considered hydrocephalic when total ventricular volumes were compared (E) F The percent difference in mean ventricular volume from control values confirmed that all ventricles expanded post-kaolin, and that proportionally the lateral ventricles increased in size significantly more than any of the other ventricles. **p < 0.01; ***p < 0.001