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Fig. 5 | Fluids and Barriers of the CNS

Fig. 5

From: Activation of Frizzled-7 attenuates blood–brain barrier disruption through Dvl/β-catenin/WISP1 signaling pathway after intracerebral hemorrhage in mice

Fig. 5

Effects of FZD7 activation on long-term neurobehavioral outcomes and iron deposition after ICH. Foot fault test (A) and rotarod test (B) on week 1, week 2, and week 3 after ICH. Quantification of probe quadrant duration in the probe trial of Morris water maze test on day 27 after ICH (C). Representative thermal imaging pictures of the probe trial (D). Swimming distance (E) and escape latency (F) of Morris water maze test on days 22 to 27 after ICH. Representative microphotographs (G, black rectangle in the left panel indicates the regions shown in the right panel under higher magnification) and quantification (H) of the Perl’s staining in the ipsilateral hemisphere. n = 6 per group. Data was represented as mean ± SD. FZD7: Frizzled-7; ICH: intracerebral hemorrhage. *p < 0.05 vs. Sham group; #p < 0.05 vs. ICH + control group; Two-way repeated measures ANOVA, Tukey’s post hoc test (A, B, E, F), and One-way ANOVA, Tukey’s post hoc test (C, H)

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Fluids and Barriers of the CNS

ISSN: 2045-8118