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Fig. 4 | Fluids and Barriers of the CNS

Fig. 4

From: Activation of Frizzled-7 attenuates blood–brain barrier disruption through Dvl/β-catenin/WISP1 signaling pathway after intracerebral hemorrhage in mice

Fig. 4

Effects of FZD7 CRISPR (activation or KO) on BBB permeability and hematoma volume. Evans blue extravasation at 24 h (A, C) and 72 h (B, E) after ICH; hemoglobin assay at 24 h (D) and 72 h (F) after ICH. The bars represent the mean ± SD. FZD7: Frizzled-7; ICH: intracerebral hemorrhage; ACT Ctrl: activation control; KO Ctrl: knockdown control; FZD7 ACT: activation of frizzled-7; FZD7 KO: knockdown of frizzled-7. n = 6 per group. *p < 0.05 vs. sham group; #p < 0.05 vs. ICH + ACT Ctrl group; &p < 0.05 vs. ICH + KO Ctrl group; @p < 0.05 vs. ICH + FZD7 KO group; One-way ANOVA, Tukey’s post hoc test

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Fluids and Barriers of the CNS

ISSN: 2045-8118