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Fig. 3 | Fluids and Barriers of the CNS

Fig. 3

From: Activation of Frizzled-7 attenuates blood–brain barrier disruption through Dvl/β-catenin/WISP1 signaling pathway after intracerebral hemorrhage in mice

Fig. 3

Effects of FZD7 CRISPR on neurobehavioral outcomes and brain edema after ICH. Modified Garcia test results of each group at 24 h (A) and 72 h (D) after ICH. Corner turn test results of each group at 24 h (B) and 72 h (E) after ICH. Limb placement test results of each group at 24 h (C) and 72 h (F) after ICH. Brain water content assessment at 24 h (G) and 72 h (H) after ICH. The bars represent the mean ± SD. FZD7: Frizzled-7; ICH: intracerebral hemorrhage; ACT Ctrl: activation control; KO Ctrl: knockdown control; FZD7 ACT: activation of frizzled-7; FZD7 KO: knockdown of frizzled-7; BG: basal ganglia; CX: cortex; Ipsi: ipsilateral; Cont: contralateral. n = 6 per group. *p < 0.05 vs. sham group; #p < 0.05 vs. ICH + ACT Ctrl group; &p < 0.05 vs. ICH + KO Ctrl group; @p < 0.05 vs. ICH + FZD7 KO group; One-way ANOVA, Tukey’s post hoc test

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Fluids and Barriers of the CNS

ISSN: 2045-8118