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Fig. 2 | Fluids and Barriers of the CNS

Fig. 2

From: Activation of Frizzled-7 attenuates blood–brain barrier disruption through Dvl/β-catenin/WISP1 signaling pathway after intracerebral hemorrhage in mice

Fig. 2

Temporal expressions of FZD7 and WISP1 along with cellular localization of FZD7 receptor after ICH. Representative western blot bands showing time course expressions of endogenous FZD7 and WISP1 (A) and densitometric quantification of FZD7 (B) and WISP1 (C) in the ipsilateral hemisphere after ICH. Data was represented as mean ± SD. FZD7 = Frizzled-7; WISP1: WNT1-inducible signaling pathway protein 1; ICH: intracerebral hemorrhage. n = 6 per group. *p < 0.05 vs. Sham group; One-way ANOVA, Tukey’s post hoc test. D Representative microphotographs of immunofluorescence co-staining of FZD7 (red) with endothelial cells (vWF, green), astrocytes (GFAP, green), and neurons (NeuN, green) at 24 h after ICH. Nuclei were stained with DAPI (blue). n = 6 per group. Scale bar = 50 μm

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