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Fig. 1 | Fluids and Barriers of the CNS

Fig. 1

From: Activation of Frizzled-7 attenuates blood–brain barrier disruption through Dvl/β-catenin/WISP1 signaling pathway after intracerebral hemorrhage in mice

Fig. 1

Experimental design. Experiment 1: Time course study and cellular localization. Experiment 2: Effects of Frizzled 7 CRISPR on short-term outcomes including neurobehavior, brain edema, BBB permeability and hematoma volume at 24 and 72 h after ICH. Experiment 3: Long term outcome study up to 28 days after ICH. Experiment 4: Mechanism study to elucidate the role of WISP1 as downstream mediator of FZD7. ICH: intracerebral hemorrhage; WB: Western blot; IF: immunofluorescence staining; CRISPR: Clustered Regularly Interspaced Palindromic Repeats; i.c.v.: intracerebroventricular

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Fluids and Barriers of the CNS

ISSN: 2045-8118