Fig. 5
From: SCO-spondin, a giant matricellular protein that regulates cerebrospinal fluid activity
Schematic illustration of von Willebrand factor polymerization, showing the domains responsible of this process. A vWF monomers dimerize intracellularly via the interaction of D1 (vWF-D plus TIL domains) and D2 at the N-terminus and the formation of a disulfide bridge between the CTCK domains at the C-terminus of the 2 monomers. B The dimers polymerize by the formation of disulfide bridges between D3 regions of adjacent dimers. C The region containing D1 and D2 is extracellularly cleaved, and the polymer acquires a threadlike structure