Fig. 1
From: SCO-spondin, a giant matricellular protein that regulates cerebrospinal fluid activity
Schematic representation of matricellular proteins, LDL receptor, and von Willebrand factor compared with SCO-spondin. Yellow box: Matricellular proteins are modular proteins, with a high prevalence of TSR, vWF-C, EGF-like, and CTCK domains. The SCO-spondin structure shares homology with several matricellular proteins, especially TSP and CCNs. Blue box: Domain structure of the LDL receptor and vWF. Both proteins have structural similarities with SCO-spondin, particularly in the ligand-binding region of the LDL receptor family (several LDLrA in tandem and 2 EGF-like domains) and in the domains responsible for polymerization of vWF (3 vWF-D domains followed by TIL domains at the N-terminus and a CTCK domain at the C-terminus). CTCK Carboxyl-terminal cystine knot, EGF Epidermal growth factor, EMI Elastin microfibril interface domain, HBD Heparin-binding domain, IGFBP insulin-like growth factor-binding protein, LDLr Low density lipoprotein receptor, SP Signal peptide, TSR Thrombospondin repeat, TSP Thrombospondin, vWF von Willebrand factor, vWF-A,C and D von Willebrand factor domain type A,C and D