Fig. 5
From: Interactions of brain, blood, and CSF: a novel mathematical model of cerebral edema
Changes in ICP with changes in resistances in the model. A Increased resistance to CSF outflow (ROUT) that occurs with non-absorptive hydrocephalus leads to the expected rise in brain intraparenchymal pressure (ICPBR). B Increased resistance to CSF flow in the ventricular system (RVEN) which is typically seen in obstructive hydrocephalus also leads to a sharp rise in ICPBR. C A rise in resistance to the bulk flow of cerebral interstitial fluid (RBF) leads to a pronounced rise in ICPBR which is characteristic of cerebral edema. D Similarly, a disruption of the blood–brain barrier (RBBB) leads to a marked rise in ICPBR as the RBBB decreases and allows more fluid to cross from the cerebrovascular compartment into the brain