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Fig. 5 | Fluids and Barriers of the CNS

Fig. 5

From: Impact of sex differences on thrombin-induced hydrocephalus and white matter injury: the role of neutrophils

Fig. 5

Pre-treatment with 17-β estradiol in male rats leads to greater ventricular dilation and more neutrophil infiltration into choroid plexus after ICV thrombin injection. A T2 weighted MRI showing ventricular volume 24 h after ICV thrombin injection in male rats pretreated with 17-β estradiol or vehicle. Quantification of ventricular volume for each group is shown in the bar chart. B Representative H&E and MPO staining images showing neutrophil infiltration into the choroid plexus 24 h after ICV injection of thrombin in male rats pretreated with 17-β estradiol or vehicle. Quantification of the number of MPO positive cells in each group is shown in the bar chart. Values are expressed as the means ± SD, n = 6, *p < 0.05 vs. vehicle treatment group. Lower magnification, scale bar = 50 μm; higher magnification, scale bar = 10 μm

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