Skip to main content
Fig. 4 | Fluids and Barriers of the CNS

Fig. 4

From: Impact of sex differences on thrombin-induced hydrocephalus and white matter injury: the role of neutrophils

Fig. 4

Intracerebroventricular injection of thrombin induces worse white matter damage and more white matter neutrophil infiltration in female compared to male rats. A Representative T2 weighted MRI showing white matter hyperintensity (outline) at 24 h after ICV injection of thrombin (3U) but not saline injection in female rats. B Quantification of white matter injury in male and female rats 24 h after ICV injection of 3U thrombin or saline. C Representative H&E and MPO staining images showing neutrophil infiltration into the white matter injury region at 24 h after ICV injection of thrombin (3U) but not saline injection in female rats. D Quantification of MPO positive cells within the white matter injury region in male and female rats 24 h after ICV injection of 3U thrombin or saline. Values are expressed as the means ± SD, n = 6 in each group; *p < 0.05, #p < 0.01 vs. saline. &p < 0.05. Lower magnification, scale bar = 50 μm; higher magnification, scale bar = 10 μm

Back to article page

Fluids and Barriers of the CNS

ISSN: 2045-8118