Intracerebroventricular injection of thrombin induced greater ventricular dilation, worse ventricular wall damage, and more neutrophil infiltration into choroid plexus in female rats compared to males.
A T2 weighted MRI showing ventricular volume at 24 h after ICV injection of 50 µl of saline or thrombin (3U) in female rats. B Representative H&E and myeloperoxidase (MPO) staining images showing neutrophil infiltration into the choroid plexus after ICV injection of thrombin but not saline. Lower magnification, scale bar = 50 μm; higher magnification, scale bar = 10 μm. C Quantification of ventricular dilation in the male and female rats. D Quantification of MPO positive cell infiltration into the choroid plexus in male and female groups. E Quantification of ventricular wall damage in the male and female groups. Values are expressed as the means ± SD, n = 6 in each group, # p < 0.01 vs. saline, *p < 0.05, **p < 0.01