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Fig. 1 | Fluids and Barriers of the CNS

Fig. 1

From: Impact of sex differences on thrombin-induced hydrocephalus and white matter injury: the role of neutrophils

Fig. 1

Intracerebroventricular injection of thrombin induced severe ventricular dilation, ventricular wall damage, and neutrophil infiltration in male rats. A T2 weighted MRI showing ventricular volume at 24 h after ICV injection of 50 µl of saline or thrombin (3U) in male rats. B Representative images of H&E staining showing ependymal denudation and rupture (arrows) at 24 h in the thrombin (3U) but not the saline group. Scale bar = 50 μm. C Representative H&E and myeloperoxidase (MPO) staining of the choroid plexus and ventricle wall 24 h after thrombin or saline injection. Note the neutrophil infiltration into the choroid plexus and the ventricular wall damage in the thrombin injection group. Lower magnification, scale bar = 50 μm; higher magnification, scale bar = 10 μm

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