Skip to main content

Table 2 Correlation analysis results

From: The CXCL13/CXCR5-chemokine axis in neuroinflammation: evidence of CXCR5+CD4 T cell recruitment to CSF

 

Total N = 57

ME n = 29

ME w/o LNB n = 22

NIMM n = 22

p-value

r-value

p-value

r-value

p-value

r-value

p-value

r-value

CSF CXCL13 levels vs. Routine CSF Parameters:

 Cell Count

 < 0.0001

0.69

0.002

0.55

 < 0.001

0.69

0.004

0.59

 QAlb

 < 0.0001

0.54

0.039

0.39

0.05

0.42

0.048

0.43

 CSF % IgG

0.83

−0.03

0.11

−0.30

0.27

−0.25

0.23

0.27

CSF CXCL13 levels vs Immune Cell Phenotypes (%):

 CD19+ 

0.004

0.38

0.57

0.11

0.64

0.10

0.005

0.57

 CD3+CD4

0.57

−0.08

0.79

−0.05

0.89

0.03

0.90

0.03

 → CXCR5+CD4

 < 0.0001

0.59

0.003

0.54

0.001

0.65

0.043

0.44

 CD3 +CD8

0.06

−0.25

0.36

−0.18

0.40

−0.19

0.09

−0.37

 → CXCR5+CD8

0.012

0.33

0.50

0.13

0.35

0.21

0.32

0.23

 CD19+vs. CXCR5+CD4 (%)

 < 0.001

0.44

0.16

0.27

0.94

−0.02

0.030

0.46

CSF CXCL13 vs. immune cell phenotypes (cells/µl):

 CD19+

 < 0.0001

0.63

0.06

0.36

0.035

0.45

 < 0.001

0.69

 CD3+CD4

 < 0.0001

0.64

0.025

0.42

0.007

0.56

0.005

0.58

 → CXCR5+CD4

 < 0.0001

0.70

0.001

0.58

 < 0.001

0.68

 < 0.01

0.60

 CD3+CD8

 < 0.0001

0.61

0.044

0.38

0.021

0.49

0.040

0.44

 → CXCR5+CD8

 < 0.0001

0.62

0.048

0.37

0.021

0.49

0.028

0.47

 

Total N = 49

ME n = 26

ME w/o LNB n = 21

NIMM n = 19

p-value

r-value

p-value

r-value

p-value

r-value

p-value

r-value

CSF CXCL13 vs. CSF/PB ratio of immune cell phenotypes (%)

 CSF/PB ratio CD19+

0.10

0.24

0.63

0.09

0.92

−0.02

0.039

0.48

 CSF/PB ratio CXCR5+CD4

0.001

0.45

0.005

0.50

0.010

0.55

0.18

0.32

 CSF/PB ratio CXCR5+CD8

0.17

0.20

0.99

−0.00

0.65

−0.10

0.29

0.25

  1. Bold values represent significant p values
  2. All calculations via Spearman Correlation and a p-value < 0.05 considered significant
  3. CSF, cerebrospinal fluid; CSF % IgG, intrathecal IgG synthesis in percent; LNB, Lyme Neuroborreliosis; ME, meningoencephalitis; NIMM, neuroimmunological disease; NIND, non-inflammatory neurological disease; PB, peripheral blood; QAlb, CSF/Serum Albumin Quotient; w/o, without