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Table 2 Odds ratios for discrimination of patients with iNPH from a group of patients with vascular dementia, progressive supranuclear palsy, multiple system atrophy, and healthy controls

From: Imaging features associated with idiopathic normal pressure hydrocephalus have high specificity even when comparing with vascular dementia and atypical parkinsonism

Univariate Multivariable
  OR (95% CI) p-value AUC OR p-value
Callosal angle 0.90 (0.88–0.93)  < 0.001 0.94 0.95 (0.92–0.99) 0.012
Temporal horns 1.96 (1.57–2.45)  < 0.001 0.84   
Evans’ index (*100) 1.61 (1.40–1.85)  < 0.001 0.93 1.51 (1.23–1.86)  < 0.001
Tight sulci 7.78 (4.62–13.08)  < 0.001 0.87   
Vent. bulgings 5.36 (3.0–9.59)  < 0.001 0.74   
Focally enl. sulci 23.72 (8.40–67.03)  < 0.001 0.73 10.18 (1.89–55.02) 0.007
Sylvian fissure 22.06 (9.80–49.66)  < 0.001 0.81 6.01 (1.42–25.40) 0.015
DESH 35.58 (13.27–95.45)  < 0.001 0.80   
PVH 1.83 (1.22–2.76) 0.004 0.63   
DWMH 1.14 (0.80–1.64) 0.47 0.54   
Radscale 2.48 (1.92–3.22)  < 0.001 0.95   
Simplified Radscale 7.16 (3.97–12.92)  < 0.001 0.96   
  1. iNPH, idiopathic normal pressure hydrocephalus; DESH, disproportionately enlarged subarachnoid-space hydrocephalus; OR, odds ratio; CI, confidence interval; AUC, area under the receiver operating characteristic curve; Vent., ventricular; enl., enlarged; PVH, periventricular hyperintensities; DWMH, deep white matter hyperintensities
  2. Each marker was tested with univariate logistic regression and a multivariable logistic regression model using forward likelihood ratio including all imaging markers except DESH and iNPH Radscale (which are combinations of several markers). The odds ratio is < 1 for Callosal angle, meaning that a higher Callosal angle is associated with lower probability of shunt responsive iNPH. The odds ratio for Evans’ index (*100) represents an increase of the variable by 0.01