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Table 2 Odds ratios for discrimination of patients with iNPH from a group of patients with vascular dementia, progressive supranuclear palsy, multiple system atrophy, and healthy controls

From: Imaging features associated with idiopathic normal pressure hydrocephalus have high specificity even when comparing with vascular dementia and atypical parkinsonism

Univariate

Multivariable

 

OR (95% CI)

p-value

AUC

OR

p-value

Callosal angle

0.90 (0.88–0.93)

 < 0.001

0.94

0.95 (0.92–0.99)

0.012

Temporal horns

1.96 (1.57–2.45)

 < 0.001

0.84

  

Evans’ index (*100)

1.61 (1.40–1.85)

 < 0.001

0.93

1.51 (1.23–1.86)

 < 0.001

Tight sulci

7.78 (4.62–13.08)

 < 0.001

0.87

  

Vent. bulgings

5.36 (3.0–9.59)

 < 0.001

0.74

  

Focally enl. sulci

23.72 (8.40–67.03)

 < 0.001

0.73

10.18 (1.89–55.02)

0.007

Sylvian fissure

22.06 (9.80–49.66)

 < 0.001

0.81

6.01 (1.42–25.40)

0.015

DESH

35.58 (13.27–95.45)

 < 0.001

0.80

  

PVH

1.83 (1.22–2.76)

0.004

0.63

  

DWMH

1.14 (0.80–1.64)

0.47

0.54

  

Radscale

2.48 (1.92–3.22)

 < 0.001

0.95

  

Simplified Radscale

7.16 (3.97–12.92)

 < 0.001

0.96

  
  1. iNPH, idiopathic normal pressure hydrocephalus; DESH, disproportionately enlarged subarachnoid-space hydrocephalus; OR, odds ratio; CI, confidence interval; AUC, area under the receiver operating characteristic curve; Vent., ventricular; enl., enlarged; PVH, periventricular hyperintensities; DWMH, deep white matter hyperintensities
  2. Each marker was tested with univariate logistic regression and a multivariable logistic regression model using forward likelihood ratio including all imaging markers except DESH and iNPH Radscale (which are combinations of several markers). The odds ratio is < 1 for Callosal angle, meaning that a higher Callosal angle is associated with lower probability of shunt responsive iNPH. The odds ratio for Evans’ index (*100) represents an increase of the variable by 0.01