Imaging features associated with idiopathic normal pressure hydrocephalus have high specificity even when comparing with vascular dementia and atypical parkinsonism

Table 1 Demographics and frequencies of dichotomous imaging markers

	iNPH, n = 55	VaD, n = 32	PSP, n = 30	MSA-P, n = 27	HC, n = 39	p-value
Age (years), median (range)	71 (56–86)	74 (60–84)	73 (61–84)	66 (45–80)	73 (58–84)	0.003^a
Sex, male	29 (53)	21 (66)	15 (50)	12 (44)	15 (39)	ns^b
Focally enl. sulci	27 (49)	2 (6)	0 (0)	3 (11)	0 (0)	< 0.001^b
Enl. Sylvian fissures	41 (75)	6 (19)	3 (10)	4 (15)	2 (5)	< 0.001^b
DESH	35 (64)	4 (13)	2 (7)	0 (0)	0 (0)	< 0.001^b
EI > 0.3	54 (98)	16 (50)	18 (60)	10 (37)	9 (23)	< 0.001^b

All data except age are n (%)
iNPH, idiopathic normal pressure hydrocephalus; VaD, vascular dementia; PSP, progressive supranuclear palsy; MSA-P, multiple system atrophy parkinsonian type; HC, healthy controls; enl., enlarged; DESH, disproportionately enlarged subarachnoid-space hydrocephalus; EI, Evans’ index; ns, not significant
^aKruskal Wallis. Mann–Whitney was used as a post hoc test between each group and revealed that there was a significant difference in age between MSA-P and all other groups (iNPH vs MSA-P, p = 0.005)
^bχ² test. All imaging markers were more frequent in iNPH than in the other groups

ISSN: 2045-8118