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Fig. 2 | Fluids and Barriers of the CNS

Fig. 2

From: Characterization of the blood–brain barrier in genetically diverse laboratory mouse strains

Fig. 2

Vascular zonation and BBB permeability are similar between different mouse strains. Immunofluorescence staining of Slc16a1 (venous and capillary EC marker, in red) (A), Vwf (venous marker, in red) (B) Asma (arterial VSMC marker, in cyan) and podocalyxin (Pdxl, endothelial lumenal marker, in blue) (A and B) in different inbred strains. Grey arrowheads point to arteries and yellow arrowheads to veins. Permeability Index (PI) to NaF of cortex (C) and hippocampus (D) in different mouse strains. The PI ratio (hippocampus/cortex) of NaF in different mouse strains (E). Pink dotted line: PI ratio = 1. Each dot indicates one mouse (C-E). N = 3–6. Female and male mice were used for analysis. Age of mice: 2 months. Data are presented as mean ± SD. PI—permeability index; HC—hippocampus; CTX—cortex. Statistical testing was performed using Kruskal–Wallis with Dunn`s multiple comparison test.*—p < 0.05. Scale bars: 30 µm

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