SARS-CoV-2: is there neuroinvasion?

Table 1 Known SARS-CoV-2 variants

Colloquially name	Scientific name: Pangolin Nextstrain	Defined by	Important mutations	Countries reported (first detected)	Increased transmissibility	Increased COVID-19 mortality or severity	Effect on vaccines
UK variant	B.1.1.7 20I/501Y.V1 VUI-202012/01	17 SNPs	-N501Y -69/70 deletion -P681H -D619G	75 (34) (United Kingdom)	Yes (~ 50–70%) [34, 35, 263,264,265,266]	Possibly [267, 268]	Oxford/AstraZeneca still effective [269]
South African variant	B.1.351 20H/501Y.V2	9 SNPs	-N501Y -K417N -E484K -D619G	32 (34) (South Africa)	Yes (~ 50%) [34, 35, 270]	Possibly [270]	Moderna may be less effective [271, 272]
Brazil variant	P.1 B.1.1.28 20 J/501Y.V3	19 SNPs	-N501Y -K417T -E484K -D619G	12 (34) (Brazil)	Yes [35]	N/A	N/A
New York	B.1.525–B.1.526 20C	13 SNPs	-D614G -E484K -Q677H -F888L	30 (Multiple)	yes	N/A	Reduction in neutralization by monoclonal antibodies
California	B.1.427–B.1.429 20C/S:452R	10 SNPS	-L452R -D624G -N501Y	N/A	Yes (~ 20%)	N/A	Reduction in neutralization by monoclonal antibodies

ISSN: 2045-8118