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Table 1 List of genes that showed loss-of-function with different sets of ciliary phenotypes and hydrocephalus

From: The regulatory roles of motile cilia in CSF circulation and hydrocephalus

Gene name

Average ciliary phenotype

Species

Defected ciliary motility

Hydrocephalus

References

Lrrc6

Normal

Mice

Yes

Yes

[121]

Hydin

Normal, stall

Mice

Yes

Yes

[122]

Dnaaf1

Normal

Mice

Yes

Yes

[123]

Lrrc48

Normal

Mice

Yes

Yes

[123]

CFAP54

Normal

Mice

Yes

Yes

[124]

Mpdz

Normal

Mice

Yes

Yes

[125]

Mdnah5

Normal

Mice

Yes

Yes

[126]

Zmynd10

Normal

Mice

Yes

Yes

[127]

Rsph9

Ciliary membrane inclusions

Mice

Yes

Yes

[115]

Ulk4

Lesser

Mice

Yes

Yes

[87]

Ccdc39

Shorter

Mice

Yes

Yes

[113]

Jhy

Shorter

Mice

Yes

Yes

[128]

Snx27

Shorter

Mice

Yes

Yes

[86]

Ccdc40

Shorter

Mice/zebrafish

Yes

Yes

[129]

Dyx1c1

Shorter

zebrafish

Yes

Yes

[130]

Celsr 1 and celsr 2

Shorter, and Lesser

Mice

Yes

Yes

[83]

Dvls (Dvl1, 2 and 3)

Shorter, and Lesser

Mice

Yes

Yes

[114]

MT1-MMP

Shorter, Lesser and Disorganized

Mice

Yes

yes

[131]

Stumpy

Absent, severely deformed

Mice

Yes

Yes

[85]

Pcdp1

 

Mice

Yes

Yes

[132]

CFAP43

 

Mice

Yes

Yes

[133]

Ccdc151

 

Mice

Yes

Yes

[134]

Foxj1

Shorter, and Lesser

Xenopus

Yes

Yes

(97)