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Fig. 7 | Fluids and Barriers of the CNS

Fig. 7

From: Increased extracellular fluid is associated with white matter fiber degeneration in CADASIL: in vivo evidence from diffusion magnetic resonance imaging

Fig. 7

Confounding effects for each variable related with lacunes and microbleeds using CIE method. CIE calculates the changes in effect estimates when each variable is added to the model sequentially in a step-wise fashion. The odds ratio for free water without adjustment was presented in the row marked as Crude. A No variable meets the CIE criterion (a threshold of 10%) for lacunes. B Only hypertension meets the CIE criterion (a threshold of 10%) for microbleeds. CIE Change-in-estimate, AFD apparent fiber density, WMHs_vol corrected volume of white matter hyperintensities by intracranial volume

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