Fig. 7From: Increased extracellular fluid is associated with white matter fiber degeneration in CADASIL: in vivo evidence from diffusion magnetic resonance imagingConfounding effects for each variable related with lacunes and microbleeds using CIE method. CIE calculates the changes in effect estimates when each variable is added to the model sequentially in a step-wise fashion. The odds ratio for free water without adjustment was presented in the row marked as Crude. A No variable meets the CIE criterion (a threshold of 10%) for lacunes. B Only hypertension meets the CIE criterion (a threshold of 10%) for microbleeds. CIE Change-in-estimate, AFD apparent fiber density, WMHs_vol corrected volume of white matter hyperintensities by intracranial volumeBack to article page