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Fig. 5 | Fluids and Barriers of the CNS

Fig. 5

From: Increased extracellular fluid is associated with white matter fiber degeneration in CADASIL: in vivo evidence from diffusion magnetic resonance imaging

Fig. 5

Abnormal diffusion metrics in WMHs: comparisons among four subregions of WMHs (FWq1-4). Alterations in in all diffusion metrics including FW, AFD, FAt, MDt, ADt, RDt, FA, MD, AD, RD (all p < 0.001) were found. The pairwise comparisons between two subregions were performed by post hoc analysis for each diffusion metric. In addition to AFD, FAt, ADt and RDt between FWq1 and FWq2 (p = 0.036, p = 0.214, p = 0.554 and p = 0.263, respectively), MDt between FWq3 and FWq4 (p = 0.06) and ADt between FWq2 and FWq3 (p = 0.025), the comparisons between two subregions for each diffusion metrics reached significance by Bonferroni adjustment. The MDt, ADt, RDt, MD, AD and RD values are in units of × 10−3 mm2/s. *Indicates Bonferroni corrected p < 0.05; **Indicates Bonferroni corrected p < 0.01; ***Indicates Bonferroni corrected p < 0.001; NS. Indicates not significant. WMHs white matter hyperintensities, FW free water, AFD apparent fiber density, FAt tissue compartment fractional anisotropy, MDt tissue compartment mean diffusivity; ADt = tissue compartment axial diffusivity, RDt tissue compartment radial diffusivity; FA = fractional anisotropy, MD mean diffusivity, AD axial diffusivity; RD radial diffusivity; FWq1-4 = four subregions of WMHs split by FW quartiles

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