Skip to main content

Table 9 Underexpressed proteins implicated in the glutamate metabolism

From: Identification of key molecular biomarkers involved in reactive and neurodegenerative processes present in inherited congenital hydrocephalus

GO-slim biological process class/child class Gene name Sum PEP Score Abundance ratio: (sample) / (control) Abundance ratio P-value: (sample) / (control)
Glutamate metabolic process     
  Proline dehydrogenase 1, mitochondrial* ** *** 149.81 1.479 0.004
  Glutamate dehydrogenase 1, mitochondrial* ** *** 376.49 1.395 0.006
Alpha-amino acid metabolic process*, cellular amino acid metabolic process*     
  CAD protein ** *** 59.22 1.389 0.008
  Thiosulfate sulfurtransferase ** *** 105.85 1.377 0.008
Carboxylic acid metabolic process**, oxoacid metabolic process**, organic acid metabolic process**     
  Beta-glucuronidase *** 7.602 2.511 2.43E-05
  Carnitine O-palmitoyltrans-ferase 1, liver isoform*** 100.58 1.354 0.024
  Pyruvate carboxylase, mitochondrial 542.37 1.458 0.002
Small molecule metabolic process***     
  Succinate-CoA ligase [GDP-forming] subunit beta, mitochondrial 80.578 1.851 0.005
  Hydroxymethyl-glutaryl-CoA synthase, mitochondrial 34.06 1.817 0.0010
  Triokinase/FMN cyclase 8.467 1.496 0.0266
  Transthyretin 48.964 2.494 1.009E-06
  1. Overexpressed proteins for glutamate metabolism in the white matter of hyh mice. *; **, *** Proteins in the classes are included in the respective child classes (see Table 8). For meaning of sum PEP score see Table 2 legend