Identification of key molecular biomarkers involved in reactive and neurodegenerative processes present in inherited congenital hydrocephalus

Table 9 Underexpressed proteins implicated in the glutamate metabolism

GO-slim biological process class/child class	Gene name	Sum PEP Score	Abundance ratio: (sample) / (control)	Abundance ratio P-value: (sample) / (control)
Glutamate metabolic process
	Proline dehydrogenase 1, mitochondrial* *	149.81	1.479	0.004
	Glutamate dehydrogenase 1, mitochondrial* *	376.49	1.395	0.006
Alpha-amino acid metabolic process, cellular amino acid metabolic process
	CAD protein *	59.22	1.389	0.008
	Thiosulfate sulfurtransferase *	105.85	1.377	0.008
Carboxylic acid metabolic process, oxoacid metabolic process, organic acid metabolic process**
	Beta-glucuronidase ***	7.602	2.511	2.43E-05
	Carnitine O-palmitoyltrans-ferase 1, liver isoform***	100.58	1.354	0.024
	Pyruvate carboxylase, mitochondrial	542.37	1.458	0.002
Small molecule metabolic process***
	Succinate-CoA ligase [GDP-forming] subunit beta, mitochondrial	80.578	1.851	0.005
	Hydroxymethyl-glutaryl-CoA synthase, mitochondrial	34.06	1.817	0.0010
	Triokinase/FMN cyclase	8.467	1.496	0.0266
	Transthyretin	48.964	2.494	1.009E-06

Overexpressed proteins for glutamate metabolism in the white matter of hyh mice. *; **, *** Proteins in the classes are included in the respective child classes (see Table 8). For meaning of sum PEP score see Table 2 legend

ISSN: 2045-8118