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Table 3 Underexpressed biological processes related to myelination and axon development

From: Identification of key molecular biomarkers involved in reactive and neurodegenerative processes present in inherited congenital hydrocephalus

GO biological process Child category Child category Number of genes process Number of genes underexpressed Expected value Fold enrichment P-value
Ensheathment of neurons (GO:0007272)    114 12 0.67 17.78 5.62E-08
  Axon ensheathment (GO:0008366)   114 12 0.67 17.78 5.62E-08
   Myelination (GO:0042552) 112 12 0.66 18.10 4.59E-08
Generation of neurons (GO:0048699)    1663 27 9.85 2.74 1.28E-02
  Neuron projection development (GO:0031175)   691 17 4.09 4.16 7.19E-03
   Axon development (GO:0061564) 373 15 2.21 6.79 6.83E-05
  1. Identification of biological processes related to underexpressed proteins in the white matter of hydrocephalic hyh mice compared with normal (wt) mice. PANTHER GO biological process complete annotation data set by application of a binomial test with Bonferroni correction for multiple testing with P < 0.05 was used. Gene ontology (GO) biological process terms are indicated. The expected value is the number of expected genes in the list for the category based on the reference list. A fold enrichment indicates that the category was overrepresented in hyh mice compared to wt mice