Identification of key molecular biomarkers involved in reactive and neurodegenerative processes present in inherited congenital hydrocephalus

Table 3 Underexpressed biological processes related to myelination and axon development

GO biological process	Child category	Child category	Number of genes process	Number of genes underexpressed	Expected value	Fold enrichment	P-value
Ensheathment of neurons (GO:0007272)			114	12	0.67	17.78	5.62E-08
	Axon ensheathment (GO:0008366)		114	12	0.67	17.78	5.62E-08
		Myelination (GO:0042552)	112	12	0.66	18.10	4.59E-08
Generation of neurons (GO:0048699)			1663	27	9.85	2.74	1.28E-02
	Neuron projection development (GO:0031175)		691	17	4.09	4.16	7.19E-03
		Axon development (GO:0061564)	373	15	2.21	6.79	6.83E-05

Identification of biological processes related to underexpressed proteins in the white matter of hydrocephalic hyh mice compared with normal (wt) mice. PANTHER GO biological process complete annotation data set by application of a binomial test with Bonferroni correction for multiple testing with P < 0.05 was used. Gene ontology (GO) biological process terms are indicated. The expected value is the number of expected genes in the list for the category based on the reference list. A fold enrichment indicates that the category was overrepresented in hyh mice compared to wt mice

ISSN: 2045-8118