Identification of key molecular biomarkers involved in reactive and neurodegenerative processes present in inherited congenital hydrocephalus

Table 11 Functionally significant underexpressed and overexpressed proteins

Gene name	Sum PEP Score	Abundance Ratio: (Sample) / (Control)	Abundance Ratio P-Value: (Sample) / (Control)
Aldehyde dehydrogenase family 1 member A3	9.87	3.63 ( >)	2.42E-07
Breast carcinoma-amplified sequence 1 homolog	79.33	0.51 ( <)	5.41E-06
Dynactin subunit 1	430.29	1.849 ( >)	1.44E-06
Dynactin subunit 4	108.84	1.58 ( >)	0.0003
Ermin	56.84	0.51 ( <)	0.0001
Galectin 1	21.94	1.61 ( >)	0.012
Gap junction gamma-3 protein	18.27	0.32 ( <)	9.09E-08
Gap junction alpha-1 protein	59.62	2.52 ( >)	1.20E-07
Gelsolin	178.38	0.72 ( <)	0.03
Neural cell adhesion molecule 1	542.26	1.62 ( >)	0.0001
Pleiotrophin	19.36	1.47 ( >)	0.03

Functionally significant underexpressed ( < ) and overexpressed ( > ) proteins in the white matter of hyh mice related to oligodendrocyte differentiation and glial reactions that may be involved in hydrocephalus pathology. For meaning of sum PEP score and PSM see Table 2 legend

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