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Table 10 Reactome pathways

From: Identification of key molecular biomarkers involved in reactive and neurodegenerative processes present in inherited congenital hydrocephalus

Reactome pathways Number of genes process Number of genes overexpressed Expected value Fold enrich-ment P-value
Formation of the ternary complex, and subsequently, the 43S complex (R-MMU-72695)* 58 17 0.41 41.89 2.79E-19
Ribosomal scanning and start codon recognition (R-MMU-72702)* 59 22 0.41 53.22 7.84E-28
Translation initiation complex formation (R-MMU-72649)* 59 22 0.41 53.22 7.84E-28
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-MMU-72662) 60 22 0.42 52.33 1.13E-27
SRP-dependent cotranslational protein targeting to membrane (R-MMU-1799339)* 90 25 0.63 39.65 8.06E-29
Formation of a pool of free 40S subunits (R-MMU-72689)* 99 27 0.69 38.92 4.01E-31
Nonsense mediated decay (NMD) independent of the Exon Junction Complex (EJC) (R-MMU-975956)** 92 25 0.64 38.78 1.38E-28
L13a-mediated translational silencing of Ceruloplasmin expression (R-MMU-156827)* 109 27 0.76 35.35 5.09E-30
GTP hydrolysis and joining of the 60S ribosomal subunit (R-MMU-72706)* 110 27 0.77 35.03 6.48E-30
Cap-dependent translation initiation (R-MMU-72737) 117 27 0.82 32.94 3.30E-29
Nonsense mediated decay (NMD) enhanced by the Exon Junction complex (EJC) (R-MMU-975957)** 113 25 0.79 31.58 2.09E-26
Nonsense-mediated decay (NMD) (R-MMU-927802)** 113 25 0.79 31.58 2.09E-26
Mitochondrial translation elongation (R-MMU-5389840)* 86 19 0.60 31.53 1.69E-19
Mitochondrial translation termination (R-MMU-5419276)* 88 19 0.62 30.82 2.59E-19
Mitochondrial translation (R-MMU-5368287)* 89 19 0.62 30.47 3.19E-19
Translation (R-MMU-72766) 225 46 1.58 29.18 7.49E-50
Nonsense mediated decay (NMD) enhanced by the Exon Junction Complex (EJC) (R-MMU-975957)** 113 25 0.79 31.58 2.09E-26
Major pathway of rRNA processing in the nucleolus and cytosol (R-MMU-6791226)** 175 25 1.23 20.39 8.25E-22
rRNA processing in the nucleus and cytosol (R-MMU-8868773)** 175 25 1.23 20.39 8.25E-22
rRNA processing (R-MMU-72312)** 175 25 1.23 20.39 8.25E-22
Metabolism of RNA (R-MMU-8953854)** 566 26 3.97 6.56 6.37E-11
Metabolism of proteins (R-MMU-392499)* 1644 59 11.52 5.12 1.03E-23
Unclassified (UNCLASSIFIED) 12,982 38 90.96 0.42 0.00E00
  1. Reactome pathways associated with the overexpressed proteins in the white matter of hydrocephalic hyh mice identified by the PANTHER data classification system. Binomial analysis with Bonferroni correction for multiple testing with corrected p < 0.05. * metabolism of proteins; ** metabolism of RNA