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Table 10 Reactome pathways

From: Identification of key molecular biomarkers involved in reactive and neurodegenerative processes present in inherited congenital hydrocephalus

Reactome pathways

Number of genes process

Number of genes overexpressed

Expected value

Fold enrich-ment

P-value

Formation of the ternary complex, and subsequently, the 43S complex (R-MMU-72695)*

58

17

0.41

41.89

2.79E-19

Ribosomal scanning and start codon recognition (R-MMU-72702)*

59

22

0.41

53.22

7.84E-28

Translation initiation complex formation (R-MMU-72649)*

59

22

0.41

53.22

7.84E-28

Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (R-MMU-72662)

60

22

0.42

52.33

1.13E-27

SRP-dependent cotranslational protein targeting to membrane (R-MMU-1799339)*

90

25

0.63

39.65

8.06E-29

Formation of a pool of free 40S subunits (R-MMU-72689)*

99

27

0.69

38.92

4.01E-31

Nonsense mediated decay (NMD) independent of the Exon Junction Complex (EJC) (R-MMU-975956)**

92

25

0.64

38.78

1.38E-28

L13a-mediated translational silencing of Ceruloplasmin expression (R-MMU-156827)*

109

27

0.76

35.35

5.09E-30

GTP hydrolysis and joining of the 60S ribosomal subunit (R-MMU-72706)*

110

27

0.77

35.03

6.48E-30

Cap-dependent translation initiation (R-MMU-72737)

117

27

0.82

32.94

3.30E-29

Nonsense mediated decay (NMD) enhanced by the Exon Junction complex (EJC) (R-MMU-975957)**

113

25

0.79

31.58

2.09E-26

Nonsense-mediated decay (NMD) (R-MMU-927802)**

113

25

0.79

31.58

2.09E-26

Mitochondrial translation elongation (R-MMU-5389840)*

86

19

0.60

31.53

1.69E-19

Mitochondrial translation termination (R-MMU-5419276)*

88

19

0.62

30.82

2.59E-19

Mitochondrial translation (R-MMU-5368287)*

89

19

0.62

30.47

3.19E-19

Translation (R-MMU-72766)

225

46

1.58

29.18

7.49E-50

Nonsense mediated decay (NMD) enhanced by the Exon Junction Complex (EJC) (R-MMU-975957)**

113

25

0.79

31.58

2.09E-26

Major pathway of rRNA processing in the nucleolus and cytosol (R-MMU-6791226)**

175

25

1.23

20.39

8.25E-22

rRNA processing in the nucleus and cytosol (R-MMU-8868773)**

175

25

1.23

20.39

8.25E-22

rRNA processing (R-MMU-72312)**

175

25

1.23

20.39

8.25E-22

Metabolism of RNA (R-MMU-8953854)**

566

26

3.97

6.56

6.37E-11

Metabolism of proteins (R-MMU-392499)*

1644

59

11.52

5.12

1.03E-23

Unclassified (UNCLASSIFIED)

12,982

38

90.96

0.42

0.00E00

  1. Reactome pathways associated with the overexpressed proteins in the white matter of hydrocephalic hyh mice identified by the PANTHER data classification system. Binomial analysis with Bonferroni correction for multiple testing with corrected p < 0.05. * metabolism of proteins; ** metabolism of RNA
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Fluids and Barriers of the CNS

ISSN: 2045-8118