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Table 1 Underexpressed biological processes related to oligodendrocyte development

From: Identification of key molecular biomarkers involved in reactive and neurodegenerative processes present in inherited congenital hydrocephalus

GO biological process category

Child category

Child category

Child category

Child category

Number of genes process

Number of genes underexpressed

Expected value

Fold enrichment

P-value

System development (GO:0048731)

    

4219

50

24.98

2.00

2.61E-03

 

Nervous system development (GO:0007399)

   

2264

38

13.40

2.84

1.82E-05

  

Neurogenesis (GO:0022008)

  

1771

31

10.48

2.96

3.26E-04

   

Gliogenesis (GO:0042063)

 

235

11

1.39

7.91

1.70E-03

    

Glial cell differentiation (GO:0010001)

185

11

1.10

10.04

1.57E-04

Anatomical structure development (GO:0048856)

    

5208

56

30.83

1.82

8.78E-03

 

Glial cell development (GO:0021782)

   

113

8

0.67

11.96

4.08E-03

  

Oligodendrocyte development (GO:0014003)

  

41

5

0.24

20.60

4.76E-02

Central nervous system development (GO:0007417)

    

835

20

4.94

4.05

1.07E-03

 

Oligodendrocyte differentiation (GO:0048709)

   

68

8

0.40

19.87

8.76E-05

  1. Identification of biological processes related to underexpressed proteins in the white matter of hydrocephalic hyh mice compared with normal (wt) mice. PANTHER GO biological process complete annotation data set by application of a binomial test with Bonferroni correction for multiple testing with P < 0.05 was used. Gene ontology (GO) biological process terms are indicated. The expected value is the number of expected genes in the list for the category based on the reference list. A fold enrichment indicates that the category was overrepresented in hyh mice compared to wt mice
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Fluids and Barriers of the CNS

ISSN: 2045-8118