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Fig. 9 | Fluids and Barriers of the CNS

Fig. 9

From: Identification of key molecular biomarkers involved in reactive and neurodegenerative processes present in inherited congenital hydrocephalus

Fig. 9

Reactive NG2-expressing cells are not astrocytes. a–e Immunofluorescence staining for NG2 (green) and GFAP (red) in whole-mounts of the neocortex from normal (wt, a) and hyh (b-d) mice. a Sixty-seven micron projection. NG2 labelling of reactive oligodendrocyte progenitor cells (OPCs, arrows, detailed in inset) and pericytes in capillaries (asterisk). Pericytes (asterisks) exhibited NG2 labelling. b, c Thirty-four micron Z projections. c In the hyh mouse, OPCs were labelled with NG2 but not with GFAP (arrows in b and c). d Pseudo 3D reconstruction (28-µm-Z projection) showing an OPC (arrow) labelled with NG2 and immunonegative for GFAP. The nuclei were stained blue with DAPI

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