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Fig. 6 | Fluids and Barriers of the CNS

Fig. 6

From: Identification of key molecular biomarkers involved in reactive and neurodegenerative processes present in inherited congenital hydrocephalus

Fig. 6

Analysis of overexpressed proteins in the white matter of hyh mice. a STRING analysis of overexpressed proteins in the white matter of hyh mice (n = 5) compared with wt mice (n = 4). Protein interactions implicated in the different biological processes presented in Tables 58, 10, and 11 are shown. The network nodes are proteins, and the edges represent the predicted functional associations. All nodes are overexpressed proteins identified in the white matter of hyh mice by proteomic analysis. The filled nodes indicate proteins with known or predicted 3D structures, and the empty nodes represent proteins with an unknown 3D structure. The edges are drawn according to the type of evidence used to predict the associations, with different coloured lines indicating the following 7 different types of evidence: fusion evidence (red line), neighbourhood evidence (green line), cooccurrence evidence (blue line), experimental evidence (purple line), textmining evidence (yellow line), database evidence (light blue), and coexpression evidence (black line). The colours of the letters, arrows, and circles (red, yellow, black, and blue) indicate their respective GO processes. b KEGG pathway map for ribosomes from Mus musculus (pathway: mmu03010). Mouse ribosomal proteins are shown in green, and proteins overexpressed in hyh mice are shown in red. The image was obtained by a valid licence from the KEGG module within Proteome Discoverer software (Thermo Scientific)

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