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Fig. 5 | Fluids and Barriers of the CNS

Fig. 5

From: Identification of key molecular biomarkers involved in reactive and neurodegenerative processes present in inherited congenital hydrocephalus

Fig. 5

Analysis of underexpressed proteins in the white matter of hyh mice. Functional enrichment analysis of the protein–protein interaction network was performed with the search tool for the retrieval of interacting genes/proteins (STRING). Protein interactions implicated in the different biological processes presented in Tables 1, 2, 3, 4, 6, 7, 9, and 11 are shown. The network nodes are proteins, and the edges represent the predicted functional associations. All nodes are query underexpressed proteins in the white matter of hyh mice (n = 5) compared with wt mice (n = 4) identified by proteomic analysis. The filled nodes indicate proteins with known or predicted 3D structures, and the empty nodes represent proteins with unknown 3D structures. The edges are drawn according to the type of evidence used to predict the associations, with different coloured lines indicating the following 7 different types of evidence: fusion evidence (red line), neighbourhood evidence (green line), cooccurrence evidence (blue line), experimental evidence (purple line), textmining evidence (yellow line), database evidence (light blue), and coexpression evidence (black line). The GO processes in which the proteins are implicated are indicated by letters, arrows, or circles of colours (black, blue, red, yellow, purple, and grey). The decrease in the level of α-Snap (N-ethylmaeimide-sensitive factor attachment protein alpha), which is characteristic of hyh mice, is shown

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