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Fig. 11 | Fluids and Barriers of the CNS

Fig. 11

From: Identification of key molecular biomarkers involved in reactive and neurodegenerative processes present in inherited congenital hydrocephalus

Fig. 11

Density of mature oligodendrocytes in the white matter. Frontal sections of the neocortex of normal (wt; a, b) and hydrocephalic hyh (c, d) mice immunostained for NG2 (green) and Olig2 (red). OPCs that were positive for NG2 also exhibited Olig2 staining in their nuclei (arrows in b and d). Mature oligodendrocytes were labelled with Olig2 but not NG2 (arrowheads in b and d). a and c correspond to 17 and 28 µm Z protections, respectively. e The proportion of mature oligodendrocytes (Olig2-positive and NG2-negative) relative to OPCs (Olig2-positive and NG2-positive) in the white matter of wt (n = 6) and hyh (n = 6) mice. f, g Representative images (1 µm thick planes) used for quantification in e. **p < 0.005; the Wilcoxon-Mann–Whitney test. gm grey matter, v lateral ventricle lumen, wm white matter. The nuclei were stained blue with DAPI

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Fluids and Barriers of the CNS

ISSN: 2045-8118