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Fig. 3 | Fluids and Barriers of the CNS

Fig. 3

From: Comparative assessment of in vitro BBB tight junction integrity following exposure to cigarette smoke and e-cigarette vapor: a quantitative evaluation of the protective effects of metformin using small-molecular-weight paracellular markers

Fig. 3

Protective effect of Metformin against A TSe and B ECe-induced loss of BBB integrity as a function of paracellular permeability to sucrose and mannitol. Treatment with Metformin at two different concentrations (10 and 20 µM) prevented the loss of BBB integrity resulting from the exposure to either TSe (A) or ECe (B) for 24 h. **p < 0.01; ***p < 0.001; ****p < 0.0001 vs. control; +++p < 0.001; ++++p < 0.0001 vs. TSe or ECe. ANOVA; n = 3 biological replicates)

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Fluids and Barriers of the CNS

ISSN: 2045-8118