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Table 5 Distribution between parenchymal and capillary enriched fraction (%)

From: Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size

 

[125I]mAb3D6-scFv8D3

[125I]di-scFv3D6-8D3

Parenchyma

Capillary

Parenchyma

Capillary

2 h

63 ± 12%

37 ± 12%

79 ± 4%

21 ± 4%

6 h

63 ± 5%

37 ± 5%

88 ± 3%

12 ± 3%

24 h

79 ± 9%

21 ± 9%

94 ± 2%

6 ± 2%

  1. Values are shown as mean ± standard deviation
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Fluids and Barriers of the CNS

ISSN: 2045-8118