Table 3 Whole blood half-lives for the fast and slow phase and AUCblood(2–24 h) for [125I]mAb3D6-scFv8D3 and [125I]di-scFv3D6-8D3
From: Brain pharmacokinetics of two BBB penetrating bispecific antibodies of different size
Ligand | Half-life (fast) | Half-life (slow) | AUCblood(2–24 h) |
|---|---|---|---|
[125I]mAb3D6-scFv8D3 | 0.3 h (0.3–0.4) | 6.1 h (5.7–6.6) | 95.2 (85.4–104.9) |
[125I]di-scFv3D6-8D3 | 0.2 h (0.2–0.3)a | 5.2 h (4.5–6.1)a | 53.7 (46.2–61.1) |