Lumbar and ventricular CSF concentrations of extracellular matrix proteins before and after shunt surgery in idiopathic normal pressure hydrocephalus

Table 2 Correlations of ECM protein levels with various clinical variables in preoperative lumbar and ventricular CSF

	B156	N194	MMP-1	MMP-2	MMP-9	MMP-10	TIMP-1
Lumbar
Age	− 0.15	0.37	0.41	0.48	0.15	-0.27	0.45
Symptom duration	− 0.09	0.07	− 0.04	0.25	− 0.22	0.27	0.31
Gait domain	0.26	0.09	0.01	− 0.38	0.01	− 0.25	− 0.37
Balance domain	0.18	0.04	0.21	− 0.25	− 0.15	− 0.08	− 0.41
Cognition domain	0.62*	0.41	− 0.18	− 0.41	0.15	− 0.28	− 0.39
Continence domain	− 0.06	0.13	0.42	0.45	0.28	− 0.16	0.31
Total inph scale	0.31	0.12	0.03	− 0.39	0.22	− 0.26	− 0.43
Daily need of sleep in hours	0.08	0.07	− 0.23	− 0.16	− 0.14	− 0.29	0.06
ΔiNPHscale score	− 0.05	− 0.25	− 0.32	− 0.09	0.00	0.11	0.02
Evans’ index	0.03	0.08	− 0.06	0.18	0.05	− 0.12	0.29
Ventricular
Age	− 0.05	0.15	0.31	0.11	0.00	− 0.30	0.57*
Symptom duration	0.37	0.52	0.02	0.45	− 0.21	0.46	0.44
Gait domain	0.26	0.19	0.06	− 0.16	0.14	0.06	− 0.27
Balance domain	0.20	0.00	0.22	− 0.11	− 0.04	0.05	− 0.15
Cognition domain	0.12	0.02	− 0.36	− 0.33	0.18	0.01	− 0.54*
Continence domain	0.13	0.12	0.40	0.14	0.18	− 0.18	0.26
Total inph scale	0.06	− 0.15	− 0.32	− 0.44	0.37	− 0.11	− 0.62*
Daily need of sleep in hours	0.18	0.16	− 0.09	0.16	− 0.30	0.00	0.17
ΔiNPHscale score	− 0.17	− 0.29	− 0.46	− 0.07	0.05	0.08	− 0.11
Evans’ index	0.37	0.50	0.03	0.39	− 0.11	0.14	0.21

Spearman correlation coefficients were calculated in correlation analyses and rho values are displayed. Results with p < 0.002 are marked with an asterisk (*). A representative peptide of brevican (B156) and of neurocan (N194) has been included. The other brevican/neurocan peptides showed correlations very similar to the representative peptides. Gait, balance, cognition and continence domain refers to iNPH scale domains
ΔiNPH scale score refers to the postoperative change in total iNPH scale score

ISSN: 2045-8118