Fig. 1

CSF concentrations of ECM proteins between lumbar and ventricular CSF before and after shunt surgery. The CNS-specific brevican and neurocan peptide concentrations did not differ between the lumbar and ventricular CSF (both pre- and post-operation), while the majority of MMPs and TIMP-1 concentrations were increased in lumbar CSF compared with ventricular CSF. MMP-9 showed opposite dynamics—its concentrations were higher in ventricular CSF compared with lumbar CSF. Friedman test with Dunn’s multiple comparisons and Bonferroni correction for multiple testing were applied to investigate the differences between the lumbar and ventricular CSF. A representative peptide of brevican (B156) and of neurocan (N194) has been displayed (see Additional file 1: Fig. S1 for all peptides). Dotted line represents change in median. LCSF lumbar CSF, VCSF ventricular CSF