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Fig. 8 | Fluids and Barriers of the CNS

Fig. 8

From: Reduction in pericyte coverage leads to blood–brain barrier dysfunction via endothelial transcytosis following chronic cerebral hypoperfusion

Fig. 8

Extravasation of EB and IgG is abolished after imatinib treatment. a Schematic representation of the procedures of imatinib treatment. b Gross anatomic changes in the Sham, Lesion, Saline and Imatinib groups after EB injection. c Confocal images showing reduced IgG extravasation in the CC after imatinib treatment. A schematic of IgG in a representative confocal microscopy image is shown in the right column. The black arrows indicate IgG accumulation outside of the vessels. d Confocal images showing reduced OPC activation in the CC after imatinib treatment. e–g Quantification of EB leakage, outside IgG density, and the number of proliferative OPC (Olig2+PCNA+) in the CC after imatinib treatment. h Schematic representation of the cascade of pathological changes following CCH. n = 10 per group; **p < 0.01 and ***p < 0.001 compared to the Sham group; ###p < 0.001 compared to the Saline group; one-way ANOVA followed by Dunnett’s post hoc test

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