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Fig. 7 | Fluids and Barriers of the CNS

Fig. 7

From: Reduction in pericyte coverage leads to blood–brain barrier dysfunction via endothelial transcytosis following chronic cerebral hypoperfusion

Fig. 7

Activation of TGF-β signaling after BBB breakdown following CCH. a Immunofluorescence staining for GFAP and pSmad2 at different timepoints. b, c Quantification of pSmad2+ cells and the pSmad2 density in the CC at different timepoints. d–f Western blotting analysis and quantification of pSmad2 and TGF-β1 expression in the CC at different timepoints. n = 5 per group; NS, not significant; *p < 0.05 and ***p < 0.001 compared to the Sham group; one-way ANOVA followed by Dunnett’s post hoc test

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