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Table 2 Pre- and postoperative values and differences in iNPH scale scores for CSF TT responders and non-responders

From: Evaluating the cerebrospinal fluid tap test with the Hellström iNPH scale for patients with idiopathic normal pressure hydrocephalus

 

CSF TT Gait responders (n = 74)

Within group differences P value

CSF TT Gait non-responders (n = 42)

Within group differences P value

Between group differences P value

CSF TT Balance responders (n = 51)

Within group differences P value

CSF TT Balance non-responder (n = 64)

Within group differences P value

Between group differences P value

Gait domain scores

 Preop

47.5 ± 19.5

 

39.5 ± 26.2

 

0.031c

42.4 ± 20.8

 

46.6 ± 23.6

 

NSa

 Postop

71.2 ± 23.7

 

49.2 ± 24.4

 

 < 0.001a

64.9 ± 23.7

 

61.4 ± 27.9

 

NSa

 Diff. preop-postop

23.7 ± 20.4

 < 0.001a

9.7 ± 16.8

0.001a

 < 0.001c

22.5 ± 21.0

 < 0.001a

14.9 ± 18.5

 < 0.001a

NSc

10 m (steps, n)d

 Preop

25.6 ± 14.0

 

32.4 ± 21.3

 

0.039c

29.1 ± 20.6

 

27.1 ± 14.2

 

NSc

 Postop

19.5 ± 5.2

 

23.0 ± 5.9

 

 < 0.001c

19.7 ± 4.5

 

20.9 ± 6.3

 

NSc

 Diff. preop-postop

6.6 ± 13.2

n = 73

 < 0.001b

9.4 ± 20.0

n = 40

 < 0.001b

NSc

9.2 ± 20.0

n = 49

 < 0.001b

6.2 ± 12.0

n = 63

 < 0.001b

NSc

10 m (time, sec)d

 Preop

15.1 ± 6.1

 

22.0 ± 18.4

 

NSc

17.4 ± 10.9

 

17.6 ± 13.6

 

NSc

 Postop

10.7 ± 4.0

 

13.9 ± 5.2

 

 < 0.001c

11.3 ± 3.6

 

12.3 ± 5.4

 

NSc

 Diff. preop-postop

4.3 ± 5.1

n = 73

 < 0.001b

8.1 ± 16.5

n = 40

 < 0.001b

NSc

6.0 ± 10.0

n = 49

 < 0.001b

5.3 ± 11.4

n = 63

 < 0.001b

NSc

Ordinal gait scale scoresd

 Preop

3 (1–7)

 

3.5 (3–6)

 

0.011c

3 (2–7)

 

3 (1–8)

 

NSc

 Postop

2 (1–4)

 

3 (2–4)

 

 < 0.001c

2 (1–4)

 

2 (1–8)

 

NSc

 Diff. preop-postop

1 (1–6)

 < 0.001b

0 (1–4)

 < 0.001b

NSc

1 (− 1–6)

 < 0.001b

1 (− 1–3)

 < 0.001b

NSc

Balance domain scores

 Preop

65.9 ± 16.4

 

55.3 ± 23.2

 

0.006c

52.2 ± 19.2

 

70.2 ± 16.5

 

 < 0.001c

 Postop

76.2 ± 12.6

 

65.7 ± 17.8

 

 < 0.001c

72.0 ± 14.2

 

72.8 ± 16.6

 

NSc

 Diff. preop-postop

10.3 ± 18.6

 < 0.00b

10.4 ± 20.6

0.002b

NS c

19.8 ± 22.4

 < 0.001b

2.6 ± 12.0

NSb

 < 0.00c

NP domain scores

 Preop

55.0 ± 18.4

 

42.5 ± 23.4

 

0.006a

51.7 ± 21.8

 

50.0 ± 20.6

 

NSa

 Postop

60.1 ± 19.5

 

48.6 ± 22.8

 

0.008a

57.8 ± 21.7

 

54.9 ± 21.4

 

NSa

 Diff. preop-postop

4.9 ± 11.3

n = 69

0.001a

4.5 ± 12.6

n = 37

0.037a

NSc

4.6 ± 12.6

n = 43

0.006a

4.6 ± 12.6

n = 60

0.007a

NSc

Continence domain scores

 Preop

60.7 ± 27.0

 

55.5 ± 25.8

 

NSc

60.9 ± 23.9

 

57.7 ± 28.5

 

NSc

 Postop

71.6 ± 26.2

 

71.0 ± 27.0

 

NSc

74.1 ± 23.3

0.001b

58.9 ± 28.4

 

NSc

 Diff. preop-postop

12.1 ± 27.4

n = 70

 < 0.00b

15.3 ± 27.7

n = 38

0.002b

NSc

14.4 ± 25.9

n = 45

 

11.6 ± 28.3

n = 61

0.003b

NSc

Total iNPH scale scores

 Preop

55.2 ± 13.3

 

45.7 ± 20.6

 

0.010 a

48.9 ± 16.3

 

54.3 ± 17.0

 

NSa

 Postop

70.3 ± 16.5

 

55.4 ± 16.7

 

 < 0.001a

65.8 ± 16.4

 

63.9 ± 19.3

 

NSa

 Diff. preop-posto

15.1 ± 14.5

 < 0.001a

9.6 ± 11.9

 < 0.001a

 < 0.001c

16.8 ± 15.0

 < 0.001a

9.7 ± 11.3

 < 0.001a

0.012c

  1. CSF TT, Cerebrospinal fluid tap test
  2. CSF TT Gait responders, improvement ≥ 5 points in the gait domain on the iNPH scale
  3. CSF TT Balance responders, improvement ≥ 16 points in the balance domain on the iNPH scale
  4. NP, Neuropsychology
  5. at-test, bRelated samples Wilcoxon signed rank test, cIndependent samples Mann–Whitney U-test. dsubtest within the gait domain. P ≤ 0.05. Values are presented as mean ± SD or median (min–max)