Skip to main content

Table 1 Patient data regarding demography, CSF space anatomy, MRI acquisitions and ICP scores

From: Direction and magnitude of cerebrospinal fluid flow vary substantially across central nervous system diseases

 

Total

REF

iNPH

cHC

SIH

AC

PC

IIH

Demographic

        

 N

94

24

34

7

8

7

11

3

 Age (years)

50.4 ± 18.8

36.1 ± 10.6

70.8 ± 6.4c

37.4 ± 11.8

50.6 ± 16.2b

42.3 ± 14.7

35.8 ± 10.4

36.7 ± 14.2

 Gender (f/m)

57/37

19/5

10/24c

4/3

6/2

5/2

10/1

3/0

 Height (m)

1.73 ± 0.09

1.72 ± 0.08

1.75 ± 0.09

1.73 ± 0.09

1.68 ± 0.06

1.75 ± 0.10

1.70 ± 0.06

1.71 ± 0.13

 Weight (kg)

81.0 ± 18.6

78.8 ± 15.8

84.0 ± 19.4

79.1 ± 28.1

76.0 ± 20.0

79.9 ± 12.4

80.5 ± 18.4

86.0 ± 26.2

 BMI (kg/m2)

26.9 ± 5.0

26.5 ± 4.9

27.0 ± 4.3

25.9 ± 6.6

26.9 ± 7.0

26.0 ± 3.1

27.9 ± 5.9

29.0 ± 6.2

 HR (beats/min)

68.4 ± 10.5

70.1 ± 12.3

68.9 ± 9.7

64.2 ± 17.3

66.3 ± 5.9

65.4 ± 7.1

68.3.9 ± 10.4

68.0 ± 7.8

CSF space anatomy

        

 Evans index

0.31 ± 0.07

0.26 ± 0.03

0.39 ± 0.03c

0.32 ± 0.03c

0.28 ± 0.03

0.27 ± 0.05

0.25 ± 0.03

0.28 ± 0.04

 Callosal angel

99 ± 28

116 ± 11

70 ± 22c

120 ± 14

116 ± 11

108 ± 18

117 ± 13

103 ± 20

 DESH

    

  Present

19 (20%)

0

19 (56%)c

0

0

0

0

0

  Absent

75 (80%)

24 (100%)

15 (44%)

7 (100%)

8 (100%)

7 (100%)

11 (100%)

3 (100%)

 Volume 4th ventricle (ml)

2.3 ± 1.7

1.4 ± 0.3

3.6 ± 2.2c

1.8 ± 0.8

1.7 ± 0.8

1.8 ± 0.7a

1.4 ± 0.6

1.8 ± 0.6

 Volume 3rd ventricle (ml)

2.0 ± 1.5

0.9 ± 0.4

3.7 ± 1.2c

1.8 ± 0.9b

1.3 ± 0.7

1.6 ± 0.9b

0.9 ± 0.4

1.2 ± 0.8

 Volume lateral ventricles (ml)

62.6 ± 61.7

18.7 ± 13.3

137.7 ± 43.2c

45.7 ± 27.5b

26.5 ± 15.1

26.8 ± 24.1

13.3 ± 7.1

34.8 ± 23.8

MRI acquisitions

        

 Intrathecal contrast-enhanced MRI (N)

88

23

30

7

8

6

11

3

 Phase-contrast MRI Aq (N)

85

23

32

5

4

7

11

3

 Phase-contrast MRI CCJ (N)

32

4

18

3

4

2

1

0

Overnight ICP

        

 Static ICP

        

 Mean ICP average (mmHg)

6.7 ± 5.7

9.4 ± 6.8

4.6 ± 5.0a

11.7 ± 6.1

3.9

–

8.0 ± 4.4

8.5 ± 4.6

 Mean ICP > 15 mmHg (%)

11 ± 22

23 ± 39

5 ± 11a

33 ± 33

0

–

10 ± 17

7 ± 6

Pulsatile ICP

        

 MWA average (mmHg)

5.1 ± 1.9

3.2 ± 0.6

5.9 ± 1.8c

5.3 ± 2.1a

3.4

–

3.5 ± 0.8

5.5 ± 0.4c

 MWA > 5 mmHg (%)

42 ± 34

4 ± 4

57 ± 31c

44 ± 32b

2

–

7 ± 6

56 ± 6c

  1. AC arachnoid cyst, Aq aqueduct, BMI body mass index, CCJ cranio-cervical junction, cHC communicating hydrocephalus, DESH disproportionately enlarged subarachnoid space hydrocephalus, HR heart rate (derived from phase-contrast MRI), ICP intracranial pressure, IIH idiopathic intracranial hypertension, iNPH idiopathic normal pressure hydrocephalus, MWA mean wave amplitude, PC pineal cyst, REF reference cohort, SIH spontaneous intracranial hypotension
  2. Differences from the REF group were determined by independent samples t-test for continuous variables and by Pearson Chi-square test for categorical variables (aP < 0.05, bP < 0.01, cP < 0.001)
Back to article page