Fig. 1From: Direction and magnitude of cerebrospinal fluid flow vary substantially across central nervous system diseasesThe degree of enrichment of tracer within supra-aqueductal ventricles illustrates the different grades of ventricular reflux. Ventricular reflux was categorized in five categories: (a) Grade 0: No signs of supra-aqueductal reflux of tracer. b Grade 1: Sign of supra-aqueductal reflux of tracer. c Grade 2: Transient enrichment of lateral ventricles about 6Â h after tracer administration. d Grade 3: Lasting enrichment of lateral ventricles, but not isointense with subarachnoid CSF, examined about 24Â h after tracer administration. e Grade 4: Lasting enrichment of lateral ventricles Day 2, with isointense T1 signal in ventricles and subarachnoid CSF after about 24Â h. The color scale to the right shows the percentage change in signal unit ratio, determined by FreeSurfer software. Notably, signal change within the parenchyma is extracted by FreeSurfer in order to only present the percentage signal change within the CSF spaces of the ventricles and the subarachnoid spaceBack to article page