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Table 2 Western blot analysis of P-gp protein expression levels in brain capillaries isolated from WT and hAPP mice (Fig. 1a)

From: Protecting P-glycoprotein at the blood–brain barrier from degradation in an Alzheimer’s disease mouse model

Protein

Wild Type

hAPP

hAPP-NCZ

hAPP-NCZ/CSA

P-gp

100 ± 13

51 ± 3*

102 ± 7

91 ± 6

  1. Data were obtained from optical density measurements and were normalized to β-actin levels; values are given as %control ± SEM (n = 3)
  2. *Indicates statistical significance determined at the 0.05 level for each endpoint compared to control using Dunnett’s many-to-one t-test
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Fluids and Barriers of the CNS

ISSN: 2045-8118