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Fig. 5 | Fluids and Barriers of the CNS

Fig. 5

From: Protecting P-glycoprotein at the blood–brain barrier from degradation in an Alzheimer’s disease mouse model

Fig. 5

NCZ lowers Aβ levels in brain capillaries. Representative confocal images of isolated brain capillaries immunostained for a hAβ40 and b hAβ42. Data after digital image analysis of membrane-associated c hAβ40- and (D) hAβ42-immunofluorescence using ImageJ. Statistics: Data per group are given as mean ± S.E.M. for 10 capillaries from one preparation [pooled tissue: WT (n = 10), hAPP (n = 15), hAPP-NCZ (n = 15), hAPP-NCZ/CSA (n = 15)]. Shown are arbitrary fluorescence units (scale 0–255). For hAβ40 p < 0.001; ***, significantly lower than control. For hAβ42, data between groups are not significantly different

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