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Table 2 Markers of pericytes expressed in healthy and diseased CNS (with BBB dysfunction)

From: Neural crest cell-derived pericytes act as pro-angiogenic cells in human neocortex development and gliomas

Pericyte marker Healthy CNS Diseased CNS
Neuron-glial antigen 2 (NG2) Development [10, 40, 80, 84, 88, 109,110,111,112] Dementia [113]
Healing wounds [114]
Neurofibromatosis [115].
Neuroinflammation [116, 117]
Tumor neovasculature [10, 87, 88, 114, 118,119,120,121,122].
Traumatic injury [123, 124]
NG2 isoforms Development [88, 125] Glioblastoma [88, 126]
Ullrich’s congenital muscular dystrophy [125]
Platelet derived growth factor receptor beta (PDGFRβ) Development [84, 127, 128]
Adult [10, 18, 40, 70, 108, 110, 129,130,131,132]
Alzheimer’s disease [129, 133, 134]
Amyotrophic lateral sclerosis [135, 136]
Angiopathies [132, 137,138,139,140,141,142]
Neuroinflammation [10, 123, 143, 144]
Tumor neovasculature [108, 145]
Alanyl aminopeptidase (CD13) Adult [10, 35, 70, 74, 128, 131, 146,147,148,149] Neuroinflammation [150]
Stroke [151]
Vimentin (VIM) Adult [39, 131, 152, 153] Angiopathies [154,155,156]
Regulator of G protein signaling 5 (RGS5) Development [157,158,159,160,161] Huntington’s disease [162]
Stroke [163,164,165,166]
Smooth Muscle α-Actin (α-SMA) Adult (pre- and post-capillary pericytes) [70, 128, 131, 167,168,169,170,171,172] Retinal angiopathy [170]
Familial form of Alzheimer’s disease [173]
Vascular endothelial growth factor (VEFG) Development [174, 175] Angiopathies [176, 177]
Neurotoxicity [178]
CXCR4 Development [179,180,181] Glioma [182, 183]
Neuroinflammation [184]
Toll-like receptor 4 (TLR4) Adult (transcriptome analysis) [185] Stroke [186, 187]
ATP binding cassette subfamily C member 9 (ABCC9) Adult [131, 188] Aging [189]
Melanoma Cell Adhesion Molecule (CD146) Development [74, 87, 190, 191] Glioblastoma [87]
Vascular cell adhesion molecule-1 (VCAM-1) FACS [192] Neuroinflammation [56]
Tumorigenesis [193]
Intercellular adhesion molecule-1 (ICAM-1) FACS [192]
Cell cultures [56]
Neuroinflammation [56, 194]
3G5-defined ganglioside Adult [195] Retinopathies [196, 197]
Angiopoietin 1 and 2 and Tie2 receptor Development [198,199,200,201] Diabetic retinopathy [202]
Neurotoxicity [175]
Stroke [203, 204]
Leptin receptor (LepRb) Development [205] Neuroinflammation [206]
Endosialin (CD248) Development [84, 207,208,209] Glioma [88, 208, 209]
Sphingosine-1-phosphate receptor 2 and 3 (S1PR2 and 3)  Adult [198, 210, 211] Stroke [211, 212]
Traumatic injury [213]
Transforming growth factor β (TGF β) Adult [198]
Cell cultures [171, 214]
Neuroinflammation [10, 215, 216]
Angiotensin 1 and 2 receptors (AT1 and AT2) Cell cultures [179, 217, 218] Diabetic retinopathy [219, 220]
ATP-gated Purinergic 2X receptor cation channel (P2X7R) Adult [221] Diabetic retinopathy [222]
Neuroinflammation [221, 223]
Zic1 Development [83]  
Potassium inwardly-rectifying channel (Kir6.1) Adult [131, 188, 224]  
Delta Like Non-Canonical Notch Ligand 1 (DLK1) Adult (microarray analysis) [188]  
Vitronectin (VTN) Development [110, 225]  
Interferon-induced transmembrane protein 1 (Ifitm-1) Development (transcriptome analysis) [110]  
Myosin light chain phosphatase (MLCP) Cell culture [226]  
Fluoro-Nissl dye NeuroTrace 500/525 Adult [227]  
Forkhead transcription factor C1 (FoxfC1) Development [83]  
Interferon-induced transmembrane protein 1(Ifitm-1) Development (transcriptome analysis) [110]  
Connexin 30 (Cx30) Adult [228]  
P-type ATPase (Atp13a5gene) Adult (transcriptome analysis) [131]  
Basic fibroblast growth factor (bFGF)   Stroke [229]
Sox2 and Klf4   Stroke [230]
protein encoded by the NOTCH3 gene   CADASIL angiopathy [231,232,233,234]
Bone morphogenetic protein 4   Alzheimer’s disease, angiopathies [235]