Table 2 Markers of pericytes expressed in healthy and diseased CNS (with BBB dysfunction)

Neuron-glial antigen 2 (NG2)

Development [10, 40, 80, 84, 88, 109,110,111,112]

Dementia [113]

Healing wounds [114]

Neurofibromatosis [115].

Neuroinflammation [116, 117]

Tumor neovasculature [10, 87, 88, 114, 118,119,120,121,122].

Traumatic injury [123, 124]

NG2 isoforms

Development [88, 125]

Glioblastoma [88, 126]

Ullrich’s congenital muscular dystrophy [125]

Platelet derived growth factor receptor beta (PDGFRβ)

Development [84, 127, 128]

Adult [10, 18, 40, 70, 108, 110, 129,130,131,132]

Alzheimer’s disease [129, 133, 134]

Amyotrophic lateral sclerosis [135, 136]

Angiopathies [132, 137,138,139,140,141,142]

Neuroinflammation [10, 123, 143, 144]

Tumor neovasculature [108, 145]

Alanyl aminopeptidase (CD13)

Adult [10, 35, 70, 74, 128, 131, 146,147,148,149]

Neuroinflammation [150]

Stroke [151]

Vimentin (VIM)

Adult [39, 131, 152, 153]

Angiopathies [154,155,156]

Regulator of G protein signaling 5 (RGS5)

Development [157,158,159,160,161]

Huntington’s disease [162]

Stroke [163,164,165,166]

Smooth Muscle α-Actin (α-SMA)

Adult (pre- and post-capillary pericytes) [70, 128, 131, 167,168,169,170,171,172]

Retinal angiopathy [170]

Familial form of Alzheimer’s disease [173]

Vascular endothelial growth factor (VEFG)

Development [174, 175]

Angiopathies [176, 177]

Neurotoxicity [178]

CXCR4

Development [179,180,181]

Glioma [182, 183]

Neuroinflammation [184]

Toll-like receptor 4 (TLR4)

Adult (transcriptome analysis) [185]

Stroke [186, 187]

ATP binding cassette subfamily C member 9 (ABCC9)

Adult [131, 188]

Aging [189]

Melanoma Cell Adhesion Molecule (CD146)

Development [74, 87, 190, 191]

Glioblastoma [87]

Vascular cell adhesion molecule-1 (VCAM-1)

FACS [192]

Neuroinflammation [56]

Tumorigenesis [193]

Intercellular adhesion molecule-1 (ICAM-1)

FACS [192]

Cell cultures [56]

Neuroinflammation [56, 194]

3G5-defined ganglioside

Adult [195]

Retinopathies [196, 197]

Angiopoietin 1 and 2 and Tie2 receptor

Development [198,199,200,201]

Diabetic retinopathy [202]

Neurotoxicity [175]

Stroke [203, 204]

Leptin receptor (LepRb)

Development [205]

Neuroinflammation [206]

Endosialin (CD248)

Development [84, 207,208,209]

Glioma [88, 208, 209]

Sphingosine-1-phosphate receptor 2 and 3 (S1PR2 and 3) 

Adult [198, 210, 211]

Stroke [211, 212]

Traumatic injury [213]

Transforming growth factor β (TGF β)

Adult [198]

Cell cultures [171, 214]

Neuroinflammation [10, 215, 216]

Angiotensin 1 and 2 receptors (AT1 and AT2)

Cell cultures [179, 217, 218]

Diabetic retinopathy [219, 220]

ATP-gated Purinergic 2X receptor cation channel (P2X7R)

Adult [221]

Diabetic retinopathy [222]

Neuroinflammation [221, 223]

Zic1

Development [83]

Potassium inwardly-rectifying channel (Kir6.1)

Adult [131, 188, 224]

Delta Like Non-Canonical Notch Ligand 1 (DLK1)

Adult (microarray analysis) [188]

Vitronectin (VTN)

Development [110, 225]

Interferon-induced transmembrane protein 1 (Ifitm-1)

Development (transcriptome analysis) [110]

Myosin light chain phosphatase (MLCP)

Cell culture [226]

Fluoro-Nissl dye NeuroTrace 500/525

Adult [227]

Forkhead transcription factor C1 (FoxfC1)

Development [83]

Interferon-induced transmembrane protein 1(Ifitm-1)

Development (transcriptome analysis) [110]

Connexin 30 (Cx30)

Adult [228]

P-type ATPase (Atp13a5gene)

Adult (transcriptome analysis) [131]

Basic fibroblast growth factor (bFGF)

Stroke [229]

Sox2 and Klf4

Stroke [230]

protein encoded by the NOTCH3 gene

CADASIL angiopathy [231,232,233,234]

Bone morphogenetic protein 4

Alzheimer’s disease, angiopathies [235]