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Table 1 Pericyte subpopulations according to ontogeny

From: Neural crest cell-derived pericytes act as pro-angiogenic cells in human neocortex development and gliomas

Origin Position Gene expression Roles
Neuroectoderm

Neural crest stem cells

Ectomesenchyme

Ectomesenchyme-derived pericytes
Forebrain Leptomeninges
Forebrain vessels
Retinal vessels
Skull, face, neck tissues
Truncus arteriosus
Mesentery (?)
[69, 75,76,77,78,79,80,81]
PAX3, PAX7, TFAP2A
[82]
FOXC1, FOXC2 [83]
Vessel development [76, 84,85,86,87]
Glioblastoma neo-vessels [87,88,89,90,91,92,93,94]
Intraembryonic Mesoderm

Lateral mesoderm (mesothelium)

Mesenchyme

Mesenchyme-derived type 1 pericytes
Lung
Heart
Liver
Gut
[69, 78, 81, 95,96,97,98]
MIXL1, TBXT [82] Absence in tumor vessels [99]
Fibrosis, myopathies [58, 81]
Intraembryonic mesoderm

Paraxial mesoderm (sclerotome)

Mesenchyme

Mesenchyme-derived type 2 pericytes
Midbrain
Hindbrain
Spinal cord
[69, 76, 78, 100, 101]
MIXL1, TBXT [82] Vessel development
Tumor neo-vessels
Glioma neo-vessels
[102, 103]
Extraembryonic mesoderm

Mesenchyme

Yolk sac-derived myeloid progenitor

Macrophage-derived pericytes
Midbrain
Rostral back skin
Retina
[104, 105]
Kcnj8, Rgs5, Dlk1, and Abcc9, TGFBR2 [105] Vascular anastomosis [106]
Retinal vascular density [107]
Tumor angiogenesis [108]