Fig. 7From: Neural crest cell-derived pericytes act as pro-angiogenic cells in human neocortex development and gliomasA pericyte conduit between facing radial vessels of the developing human cerebral cortex. a–c Two pericytes (P) are located at the opposite terminals of an NG2+collagen IV+ bridging conduit; as often observed, their nucleus marks the point of TNT/MT origin. d The enlargement of the merged image in c reveals further details and shows that in both the PCs, the nucleus is bent over on itself, describing a phrygian hat-like shape, so leaving an opening directly communicating with the lumen of the parental vessel; the entrance to the ‘tunnel’ is revealed by the collagen IV-enriched endothelial layer of the vessel basal lamina (red arrow). This critical passage is better shown in the single optical plane from the z-stack (e, red arrow); note the nucleus of an EC (white arrow) engaged through a collateral root. Human telencephalon 22 weeks of gestation. Scale bars a-e 25 µmBack to article page