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Fig. 4 | Fluids and Barriers of the CNS

Fig. 4

From: Neural crest cell-derived pericytes act as pro-angiogenic cells in human neocortex development and gliomas

Fig. 4

First steps in human dorsal telencephalon vascularization. ac Sequence of cerebral cortex formation and vascularization at 9/9.5 weeks of gestation (a, pre-plate; PP), 10 weeks of gestation (b, early cortical plate; eCP), and 12 weeks of gestation (c, developing cortical plate; dCP): the newly penetrated microvessels are lined by von Willebrand factor (vWF)-reactive ECs and surrounded by collagen IV (a, b) and by collagen IV and laminin (c); note in c a penetrating microvessel (arrow) that branches in the subventricular zone (SVZ) and forms a loop-like anastomosis (asterisk). df During these early phases of cerebral cortex vascularization, ECs express the BBB-specific transporter Glut1 and are enwrapped by a continuous layer of NG2+ PCs (arrow). df Human telencephalon 12 weeks of gestation. Scale bars a 40 µm; b 10 µm

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