Fig. 10

CXCL12/CXCR4 ligand receptor system interaction on ECs and PCs. a Radial glia stains for CXCL12 and forms extensive contacts with the CXCR4⁺ vessel wall; CXCR4 also marks neuroblasts nuclei. b CXCR4 reveals forebrain PCs (arrows), while CXCL12 is prevalent on ECs (arrowheads). c CXCR4 stains the wall of a vessel collateral and its PCs (arrow). d Enlargement of the pericyte shown in c (arrow) and a tract of CXCL12/CXCR4 colocalization on the vessel wall (arrowhead). CXCR4 nuclear expression in neuroblasts is the hallmark of their activated phenotype [346, 347]. Human telencephalon 22 weeks of gestation. Scale bars a, b 10 µm; c, d 25 µm