Fig. 6
From: Transfer of rhodamine-123 into the brain and cerebrospinal fluid of fetal, neonatal and adult rats
Comparison between R123 transfer into the brain with abcb1a (PGP) levels in the brain at different stages of development. Average concentration ratios for the restriction of R123 transfer into the brain ([plasma]/[brain]) at E19, P4, P14 and adult (P42+) are listed as a ratio compared to adult (red squares). Data are the same as Fig. 5. The average level of abcb1a (PGP) in the rat brain at E13, E15, E18, P1, P7, P21 and adult (P42+) as measured in [11], listed as a ratio compared to adult (blue, circles). Age is on the x-axis, with embryonic day (E) before birth and postnatal day (P) after birth. Note the positive gradient both lines, with abcb1a levels in the brain and restriction of PGP substrate R123 entry into the brain both increasing with age. Linear regression lines of best fit are shown for R123 restriction (red; R2 = 0.98) and abcb1a levels (blue; R2 =0.92)